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Non-GLP-1RA users (unexposed) were individuals with no record of GLP-1RA prescriptions before the index date

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To understand how semaglutide interacts with the body over time, what semaglutide does to your body is a useful read

4.5 Macrophages Macrophages sense HBV infection mainly through pattern recognition receptors (PRRs) such as TLR4, TLR2, and other DNA sensors like cGAS-STING that detect viral components, HBV DNA, HBsAg, and core proteins (80)